Inhibin B Is the Major Form of Inhibin/Activin Family Secreted by Granulosa Cell Tumors
نویسندگان
چکیده
منابع مشابه
Granulosa Cell – Stromal Tumors: An Immunohistochemical Study Including Comparison of Calretinin and Inhibin
Background and Objective: Histopathological evaluation of granulosa cell tumors (GCT) of the ovary may be confused morphologically with a wide variety of the tumors. Immunohistochemical staining for inhibin and calretinin can be used for better diagnosis. Although it has been suggested that inhibin can be a sensitive marker for GCT, it maybe had negative results in some cases. In addition, cal...
متن کاملThe effect of exosomes derived from human ovarian epithelial cancer cells on the secretion of AMH and Inhibin in granulosa cells
Exosomes are secreted by different types of cells and known as biological packages. Exosomes have significant role in intercellular communications and involved in the development and progression of various diseases such as cancer. Inhibin B and anti-mullerian hormone (AMH) are markers of granulosa cell tumors (GCT) and due to the role of exosomes in the progression of cancer, in this experiment...
متن کاملgranulosa cell – stromal tumors: an immunohistochemical study including comparison of calretinin and inhibin
background and objective: histopathological evaluation of granulosa cell tumors (gct) of the ovary may be confused morphologically with a wide variety of the tumors. immunohistochemical staining for inhibin and calretinin can be used for better diagnosis. although it has been suggested that inhibin can be a sensitive marker for gct, it maybe had negative results in some cases. in addition, cal...
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Part of heterodimeric inhibin, inhibinis crucial for mammalian ovarian function. Regulation of inhibinexpression in granulosa cells is both endocrine, primarily by follicle-stimulating hormone (FSH), and paracrine, primarily by members of the transforming growth factor (TGF) superfamily. Smad proteins transmit TGFsignals to the nucleus, but the cooperating transcription factors involved in inhi...
متن کاملImmunohistochemical significance of ER alpha, inhibin A, calretinin, and Ki67 expression in granulosa cell ovarian tumors.
Adult granulosa cell tumors (AGCTs) have a heterogeneous morphology and an unpredictable behavior, which can lead to a misinterpreted diagnosis. The aim of our study was to assess the immunoexpression of estrogen receptor (ER) alpha, Ki67, calretinin, and inhibin A in AGCTs, in order to evaluate their value in diagnosis and prognosis of this type of tumor. Immunohistochemical stainings for thes...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 1998
ISSN: 0021-972X
DOI: 10.1210/jc.83.3.1029